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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Dina Abbas Ahmed

Basic information

Name : Dina Abbas Ahmed
Title: Lecturer of Analytical Chemistry
Personal Info: Dina Abbas, Assistant Lecturer of Analytical Chemistry - Department of pharmaceutical Chemistry. She has a Bachelor Degree in Pharmacy from Ain Shams university with highest honors degrees. View More...

Education

Certificate Major University Year
PhD Analytical chemistry Faculty of Pharmacy - Cairo University 2020
Masters Pharmaceutical Chemistry Faculty of Pharmacy - Ain Shams University 2015
Bachelor . Faculty of Pharmacy - Ain Shams University 2006

Teaching Experience

Name of Organization Position From Date To Date
GlaxoSmithKline, Egypt Quality Assurance and Production Departments 01/07/2005 01/09/2006
Dr. Ezzat Zeyada Pharmacy Pharmacist 06/07/2004 06/09/2004
Cairo Lab Analyist 01/06/2004 01/07/2004
Ali's Image Pharmacies Pharmacist 01/07/2003 01/08/2003
GlaxoSmithKline Quality Control Department 01/07/2002 01/09/2002

Researches /Publications

• Synchronous UPLC Resolution of Aceclofenac and Diacerin in Their Powdered Forms and Matrix Formulation: Stability Study” - 01/0

DINA ABBAS AHMED MOSTAFA

Mohamed K Abd El-Rahman, Soheir A Weshahy

01/06/2020

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Smart spectral processing of data for the estimation of commonly used over the counter (OTC) co-formulated; Pseudoephedrine hydrochloride and Ibuprofen - 01/1

DINA ABBAS AHMED MOSTAFA

Dina A. Ahmed, Mohamed K. Abd El-Rahman, Soheir A. Weshahy

01/12/2019

Oral pharmaceutical preparation containing pseudoephedrine hydrochloride (PSE) and ibuprofen (IBU) is widely prescribed as over- the- counter (OTC) for treatment of common cold-sinus. Development of four precise and accurate spectrophotometric methods are established for the concurrent determination of (PSE) and (IBU)in this preparation exploiting zero and/or ratio spectra. Method I is a dual wavelength method (DW). method II is a ratio difference method (RD), method III is a constant multiplication coupled with spectrum subtraction method (CM-SS) and method IV is a constant center coupled with spectrum subtraction method (CC-SS). While, absorbance correction method (AC) is successfully established for the determination of (IBU) only exploiting zero order absorption spectra. The calibration curves are linear over the concentration range of 100.0–900.0 μg/mL for (PSE) and 200.0–1000.0 μg/mL for (IBU). No separation steps are required for the spectrophotometric procedures which augments their simplicity. Analyzing synthetic mixtures of the cited drugs evaluated the specificity of the applied methods. Validation of the analysis results have been statistically performed confirming the accuracy and reproducibility of the proposed method through recovery studies which were carried out by following ICH guidelines. Thus, the developed methods can be successfully applied routinely in quality control laboratory.

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Study of efficiency and spectral resolution for mathematical filtration technique using novel unlimited derivative ratio and classical univariate spectrophotometric methods for the multicomponent determination-stability analysis - 01/0

DINA ABBAS AHMED MOSTAFA

Mohamed Khaled Abdel Rahman, Soheir Abdel Fattah Weshahy,

01/05/2019

Six simple, sensitive and selective spectrophotometric methods based on mathematical filtration technique are presented for concurrent determination of aceclofenac (ACE) and paracetamol (PAR) in presence of their degradation products, namely; diclofenac sodium (DIC) and 4-aminophenol (4-AP), respectively without preliminary physical separation procedures. This technique consists of several consecutive steps applied on built-in spectrophotometer software utilizing zero and/or derivative and/or ratio spectra of the studied components. These methods, namely, dual wavelength (DW), induced dual wavelength (IDW), derivative subtraction (DS) coupled with constant multiplication (CM), ratio difference method (RD), constant center method (CC) and the novel introduced unlimited derivative ratio method (UDD). This novel method has a very powerful competence for the analysis of the challengeable mixtures lacking zero crossing point. The linearity, accuracy and precision ranges of these methods were determined and validated as per ICH guidelines. Moreover, the specificity was checked by analyzing synthetic mixtures of both drugs. These methods were applied for the determination of the cited drugs in pharmaceutical formulation and a statistical comparison of the obtained results was made with each other and with those of reported spectrophotometric method. The comparison of the results of pure powder form showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

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Double-Dip Approach: Simultaneous Dissolution Profiling of Pseudoephedrine and Ibuprofen in a Combined Dosage Form by Ion Selective Electrodes - 01/1

DINA ABBAS AHMED MOSTAFA

Soheir A. Weshahy , Mohamed K. Abd El-Rahman ,

01/11/2018

Attainment of the dissolution silhouettes of active ingredients in a pharmaceutical formulation containing multiple components is governed by off-line multistep chromatographic and spectroscopic methods. In this work, “Double-Dip” green analytical chemistry (GAC) approach with the eventual aim of progressing in-line potentiometric sensors for simultaneous attainment of the dissolution curves of dual active ingredients in a binary pharmaceutical dosage form is adopted. For the proof of concept, two selective and sensitive sensors were elaborated for the simultaneous detection of the cationic Pseudoephedrine (PSE) and the anionic Ibuprofen (IBU) drugs as well as monitoring their dissolution silhouettes. For detecting the cationic drug (PSE), PSE sensor was elaborated by the usage of potassium tetrakis (4-chlorophenyl)borate (KTCPB) being a cationic exchanger, while IBU sensor was established for detecting the anionic IBU using tridodecylmethyl ammonium chloride (TDC) being an anionic exchanger and 2-nitrophenyl-octyl-ether (2-NPOE) as a plasticizer for both sensors. Developing these novel sensors permits PSE and IBU's detection in bulk powder, in laboratory combinations and in complex dosage form and also their simultaneous in-line monitoring of their dissolution profiles. The benefits of the newly introduced “Double-Dip” approach are emphasized with a notably curtailing in solvent consumption and waste generation

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