Future University In Egypt (FUE)
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Nada El Hoffy

Basic information

Name : Nada El Hoffy
Title: Lecturer
Personal Info: Nada El Hoffy, lecturer at Pharmaceutics and Pharmaceutical Technology Department. She got her Master Degree from Cairo University. Nada started her teaching career as a teaching assistant, Ahram Canadian University and then moved to the British University in Egypt on August, 2006 and finally joined FUE on March, 2009. View More...


Certificate Major University Year
PhD Pharmaceuticals Cairo University - Faculty of Pharmacy 2017
Masters (Pharmaceutical Sciences (Pharmaceutics Cairo University - Faculty of Pharmacy 2013
Bachelor Pharmaceutical Sciences Cairo Universty - Faculty of Pharmacy 2004

Teaching Experience

Name of Organization Position From Date To Date
British University in Egypt, Faculty of Engineering Teaching Assistant 01/01/2006 01/01/2009
Ahram Canadian University, Faculty of Pharmacy Teaching Assistant 01/01/2005 01/01/2006

Researches /Publications

In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration. - 01/0


M. Haider , M. Ibrahim


Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release. A parallel design was adopted to evaluate the pharmacokinetic performance of DTZ-loaded niosomes in male Wistar rats. Non-compartmental analysis was performed where Cmax, Tmax, t1/2, MRT, area under the release curve (AUC) and Ke were assessed. The prepared niosomes were spherical with mean particle size 0.82–1.59 μm. Span 60-cholesterol niosomes (1:1 molar ratio) showed the highest entrapment and release efficiencies. In vivo study revealed an increase in MRT, t1/2 and AUC with a decrease in Ke. In conclusion, nasal niosomal formulation of DTZ expressed suitable pharmacokinetic parameters and bioavailability through prolonged duration of action inside the body as well as low rate of elimination depicting a promising alternate to the conventional oral route.

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