Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Maha Osama Abdelaziz Mohamed Elkayal

Basic information

Name : Maha Osama Abdelaziz Mohamed Elkayal
Title: Lecturer
Personal Info: Maha Osama, Lecturer at Pharmaceutics and Pharmaceutical Technology Department. She got her Master degree Mansoura University.

Education

Certificate Major University Year
PhD Pharmaceutical Sciences Ain Shams University - Faculty of Pharmacy 2019
Masters Pharmaceutical Sciences Mansoura University 2009
Bachelor . Mansoura University - Faculty of Pharmacy 2003

Teaching Experience

Name of Organization Position From Date To Date
جامعة المنصورة كلية الصيدلة 01/01/2003 01/01/2011

Researches /Publications

OPTIMIZATION OF THE COLLOIDAL PROPERTIES OF DIFFERENT VESICULAR SYSTEMS AIMING TO ENCAPSULATE (-)-EPIGALLOCATECHIN-3-GALLATE. - 01/0

Maha Osama Abdelaziz Mohamed Elkayal

Nasr M, Mortada N, Elkheshen S.

01/01/2020

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Colloidal (-)- epigallocatechin-3-gallate vesicular systems for prevention and treatment of skin cancer: A comprehensive experimental study with preclinical investigation - 01/0

Maha Osama Abdelaziz Mohamed Elkayal

Maha Nasr, Nahed Mortada

01/09/2019

Skin carcinogenesis is a common malignancy affecting humans worldwide, which could benefit from nutraceuticals as a solution to the drawbacks of conventional skin cancer treatment. (−)-epigallocatechin-3-gallate (EGCG) is a promising nutraceutical in this regard; however, it suffers chemical instability and low bioavailability resulting in inefficient delivery. Therefore, EGCG encapsulation in ultradeformable colloidal vesicular systems, namely: penetration enhancer-containing vesicles (PEVs), ethosomes and transethosomes (TEs) for topical administration has been attempted in this study to overcome the problems associated with the use of free EGCG. The prepared vesicles were characterized for their entrapment efficiency, TEM visualization, chemical compatibility, antioxidant properties, ex-vivo skin deposition, photodegradation and physical stability after storage. Most of the prepared vesicles exhibited reasonable skin deposition and preservation of the inherent antioxidant properties of EGCG with good physical stability. EGCG-loaded PEVs and TEs exhibited an inhibitory effect on epidermoid carcinoma cell line (A431) in addition to reduced tumor sizes in mice, confirmed with histopathological analysis and biochemical quantification of skin oxidative stress biomarkers; glutathione, superoxide dismutase and catalase, as well as lipid peroxidation. EGCG PEVs succeeded in offering an effective delivery system targeting skin cancer, which is worthy of further experimentation.

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Awards

Award Donor Date
Non Non 2009

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