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Suzan Mansour

Basic information

Name : Suzan Mansour
Title: Lecturer
Personal Info: Dr. Suzan Mansour, Lecturer in Pharmacology and Toxicology and Biochemistry department. She has got her Masters & PhD degrees from Cairo University.

Education

Certificate Major University Year
PhD Pharmaceutical Sciences -Drugs and toxins Faculty of Pharmacy - Cairo University 2012
Masters Pharmaceutical Sciences Faculty of Pharmacy - Cairo University 2009
Bachelor Pharmaceutical Sciences Faculty of Pharmacy - Cairo University 2003

Researches /Publications

Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation‐induced testicular injury. - 01/0

Suzan Mohamed Mohamed Mansour

Ibrahim RY

01/01/2020

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Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation‐induced testicular injury - 01/1

Suzan Mohamed Mohamed Mansour

Rasha Y. M. Ibrahim

01/10/2019

Objectives Combined chemotherapy and radiotherapy usually associated with various comorbidities especially on rapidly proliferating cells as testis. This study aimed to characterize main constituents of Ocimum basilicum L. (OB) aqueous extract and examine its protective effect on doxorubicin/irradiation (DOXO/IR)‐induced testicular injury in rats. Methods Spectrophotometric analysis showed considerable amount of polyphenolic (146.31 µg/mg) and flavonoid contents (28.63 µg/mg); UPLC‐ESI‐MS/MS analysis revealed that the major flavonoid was apigenin‐O‐glucoside (7.53%) followed by luteolin (5.94%), while rosmarinic acid was the major polyphenolic (15.76%) followed by caftaric acid (9.39%); rutin and querctin were also present and were quantified using high‐performance liquid chromatography. Administration of OB extract (200 mg/kg per day; p.o.) to DOXO/IR rats resulted in marked improvement of associated testicular damage. Key findings Ocimum basilicum L. significantly decreased testicular levels of nuclear factor‐kappa B and B‐cell lymphoma‐2 (Bcl2)‐associated protein X, along with caspase‐3 immunohistochemical staining. In addition, OB elevated testicular total antioxidant capacity, nuclear erythroid‐related factor‐2, Bcl2 and testosterone contents and Ki‐67 immunohistochemical staining. Such changes were also accompanied by restoration of testicular architecture. Conclusions The study highlights the protective role of OB aqueous extract in hampering most of the harmful chemotherapy/radiotherapy‐induced outcomes via its antioxidant, antiapoptotic and cell regeneration abilities. Such findings may offer an incentive in expanding its use during chemotherapy and radiotherapy.

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Venlafiaxine alleviates complete Freund’s adjuvant-induced arthritis in rats:Modulation of STAT-3/IL-17/RANKL axis - 01/0

Suzan Mohamed Mohamed Mansour

Kamel M. Kamel, Amany M. Gad, Marwa M. Safar, Hala M. Fawzy

01/06/2019

Aims Rheumatoid arthritis is usually accompanied by various comorbidities especially on the psychological side such as depression. This study aimed at revealing the potential curative effects of venlafaxine (VFX), a serotonin/norepinephrine reuptake inhibitor (SNRI), on experimentally-induced arthritis in rats. Methods Arthritis was induced by injecting complete Freund's adjuvant (CFA, 0.1 ml, s.c.). One day thereafter, VFX (50 mg/kg, p.o.) was given for 21 days. Methotrexate was used as a standard disease modifying anti-rheumatic drug. Key findings CFA injection caused prominent arthritis evident by the increase in the hind paw and ankle diameter accompanied by elevating tumor necrosis factor-alpha, interleukin-6, interleukin-17 and matrix metalloproteinase-3 levels, effects that were diminished by VFX. Moreover, VFX down regulated gene expressions of receptor activator of nuclear factor kappa-B (NF-кB) ligand and signal transducer and activator of transcription-3 beside hampering immunohistochemical expression of vascular endothelial growth factor and NF-кB. This SNRI also improved the oxidant status of the hind limb as compared to the arthritic group. Nonetheless, MTX was better in amendment of arthritis authenticated by its effect on some inflammatory and oxidative stress biomarkers. Significance This study provides a novel therapeutic use of VFX as a considerable anti-arthritic drug and offers an incentive to expand its use in RA.

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Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension - 01/0

Suzan Mohamed Mohamed Mansour

Bhavani Prasad Vinjamuri, Rehab N. Shamma, Mahmoud M. Ghorab, Mahavir Bhupal Chougule,Lipika Chablani

01/05/2019

Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried hydrogel microparticles containing biodegradable sodium carboxymethyl cellulose, sodium alginate, and sodium hyaluronate polymers at variable concentrations were prepared. A design of experiment using the “Extreme Vertices Mixture” design was executed. The design was used to study the influence of polymer concentration and their interactions on the physicochemical properties of the formulations in terms of particle size, particle size distribution, product yield, entrapment efficiency, and in-vitro drug release. Selected formulations were also evaluated for swelling, biodegradation, moisture content, in-vitro aerodynamic performance, and cytotoxicity. In addition, a lung deposition and pharmacokinetic study was conducted in rats to study drug accumulation in lungs and blood after intratracheal administration of the spray dried inhalable hydrogel microparticles in comparison to orally administered Viagra®. The results demonstrated that formulated microparticles had a mean geometric particle size between 2 and 5 μm, entrapment efficiency of >80%, and yield ranging between 47 and 66% w/w. The in-vitro drug release profiles showed a sustained drug release of sildenafil citrate for over 24 h. The statistical design showed a significant influence of the microparticulate composition on the physicochemical properties. Furthermore, selected formulations were evaluated for their aerodynamic properties. The aerodynamic properties included fine particle fraction ranging between 24 and 30%, dose recovery percent of 68–8 5%, and average mass median aerodynamic diameter of 4.6–4.8 μm. The in-vivo pharmacokinetic study showed that inhaled spray dried hydrogel microparticles (M6) formulation had significantly higher lung/blood Cmax, AUC, extended half-life, and mean residence time in comparison to orally administered sildenafil citrate of the same dose. In conclusion, the formulated drug-loaded spray dried hydrogel microparticles showed promising in-vitro and in-vivo results for the pulmonary delivery of sildenafil citrate. The spray dried hydrogel microparticles formulation can be considered as a potential alternative of oral sildenafil citrate for treatment of PAH.

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Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund’s Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-кB - 01/1

Suzan Mohamed Mohamed Mansour

Kamel M. Kamel. Amany M. Gad, Marwa M. Safar, Hala M. Fawzy

01/10/2018

Articular manifestations are the main hall mark for rheumatoid arthritis; inflammation and oxidative stress are involved in its pathogenesis. This study was designed to figure out the possible therapeutic potential of polydatin on experimentally induced arthritis in rats. Polydatin (POLY) was administered (200 mg/kg, p.o.) for 21 days to complete Freund’s adjuvant (CFA; 0.1 ml, s.c.)-induced arthritic rats. Meanwhile, methotrexate (MTX; 0.75 mg/kg, i.p.) was given as a reference standard disease-modifying anti-rheumatic drug (DMARD). Both POLY and MTX significantly attenuated articular damage associated with CFA-induced arthritis. This was manifested by reducing levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), interleukin-17 (IL-17), and matrix metalloproteinase-3 (MMP-3), paralleled with marked decrease in hind paw and ankle diameters. Moreover, POLY and MTX downregulated gene expressions of receptor activator of nuclear factor kappa-B ligand (RANKL) as well as signal transducer and activator of transcription-3 (STAT3) besides hampering immunohistochemical staining of vascular endothelial growth factor (VEGF) and nuclear factor kappa-B (NF-κB). Furthermore, substantial decline in myeloperoxidase (MPO) activity and malondialdehyde (MDA) level associated with significant rise in reduced glutathione content (GSH) was observed. These findings provide an innovative therapeutic approach of POLY as a natural anti-arthritic drug through modulating IL-6/STAT-3/IL-17/NF-кB cascade.

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