Future University In Egypt (FUE)
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Ola Gamal

Basic information

Name : Ola Gamal
Title: Assistant Lecturer
Google Schoolar Link
Personal Info: Ola Gamal, Teaching Assistant of Analytical Chemistry - Department of pharmaceutical chemistry. Graduated from faculty of pharmacy future university in egypt Class 2013.


Certificate Major University Year
Masters 2021
Bachelor 2013

Researches /Publications

Impressive merger between green analytical approaches and quality- by- design for alcaftadine determination in eye drops and rabbit aqueous humor; application to stability study by two validated chromatographic methods

Ola Gamal Hussein Farrag

Mamdouh R. Rezk; Mohamed Abdelkawy; Yasmin Rostom



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Exquisite integration of quality-by-design and green analytical approaches for simultaneous determination of xylometazoline and antazoline in eye drops and rabbit aqueous humor, application to stability study

Ola Gamal Hussein Farrag

Mamdouh R. Rezk; Mohamed Abdelkawy; Yasmin Rostom



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Green TLC-Densitometric Method for Simultaneous Determination of Antazoline and Tetryzoline: Application to Pharmaceutical Formulation and Rabbit Aqueous Humor

Ola Gamal Hussein Farrag

Yasmin Rostom; Mohamed Abdelkawy; Mamdouh R. Rezk



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Spectrophotometric platform windows' exploitation for the green determination of Alcaftadine in presence of its oxidative degradation product

Ola Gamal Hussein Farrag

Yasmin Rostom; Mohamed Abdelkawy; Mamdouh R. Rezk



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Novel Stability-Indicating TLC-Densitometric Method for Quantification of Antazoline and Tetryzoline; Application to Pharmaceutical Formulation

Ola Gamal Hussein Farrag

Mohamed Abdelkawy, Mamdouh R. Rezk, Yasmin Rostom



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Novel solid-contact ion-selective electrode based on a polyaniline transducer layer for determination of alcaftadine in biological fluid

Ola Gamal Hussein Farrag

Mohamed Abdelkawy; Mamdouh R. Rezk; Amr M. Mahmoud; Yasmin Rostom



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Analytical Eco-Scale for Evaluating the Greenness of Advanced Voltammetric Method Used for the Simultaneous Analysis of combined urinary tract infection drugs in different matrices

Ola Gamal Hussein Farrag

Eman S. Elzanfaly; Hala E. Zaazaa; Shimaa A. Atty



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Stability Indicating TLC–Densitometric Method for Determination of Alcaftadine in Presence of its Degradation Products and Dosage form Preservatives

Ola Gamal Hussein Farrag

Aya T. Soudi, Ola G. Hussein, Eman S. Elzanfaly and Hala E. Zaazaa.


Stability indicating methods are essential to determine the stability of newly developed dosage forms. In this work a simple stability-indicating thin-layer chromatographic (TLC) method was developed and validated to determine Alcaftadine in presence of its main degradation products and preservative benzalkonium chloride in bulk powder and in pharmaceutical formulations. Separation was developed on TLC aluminum plates precoated with silica gel 60F-254 as a stationary phase using chloroform: methanol: ammonia (5:5:0.1, by volume) as a developing system. Densitometric scanning was carried out in the absorbance mode at 282nm. Alcaftadine was subjected to oxidation, acid and alkaline hydrolysis. It was observed that the drug is susceptible to oxidation only. Method validation was carried out according to ICH guidelines and the proposed method was successfully applied to analyze alcaftadine in pharmaceutical dosage form with no interference from dosage form additives or preservatives. Linearity range was found to be 0.50 - 12.00µg/band with a good linear relationship r of 0.9998. Results obtained by the proposed TLC-densitometric method were statistically compared with those obtained by a reported spectrophotometric method and no differences were found.

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