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Manal Kandeel

Basic information

Name : Manal Kandeel
Title: Professor of Pharamceutical Organic Chemistry, Vice dean of Post Graduate and Research Affairs
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Personal Info: Professor Manal kandeel, Professor of Pharmaceutical Organic Chemistry - Department of Pharmaceutical Chemistry, Vice dean of Post Graduate and Research Affairs. She received her Ph.D. form Faculty of Pharmacy, Cairo University. Professor Manal was working as Vice Dean for Community Service and Environment Development, Faculty of Pharmacy, Cairo University, in 2011, the Faculty has been accredited by the National Authority for Quality Assurance and Accreditation of Education (NAQAAE). View More...


Certificate Major University Year
PhD Organic Chemistry Cairo University 1987
Masters Organic Chemistry Cairo University 1982
Bachelor Pharmaceutical Sciences Cairo University 1976

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmacy, Cairo University Vice Dean for Post Graduate Studies and Research Affairs 01/10/2011 07/05/2014
Faculty of Pharmacy, Cairo University Acting Dean 01/09/2011 01/10/2011
Faculty of Pharmacy, Cairo University Acting Vice Dean for Post Graduate Studies and Research Affairs 01/08/2011 01/10/2011
Faculty of Pharmacy, Cairo University Vice Dean for Community Service and Environment Development 01/08/2009 01/10/2011
Faculty of Pharmacy, Beni-Suef University Head of Organic Chemistry Department 01/10/2005 01/06/2010
Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA) Head of Organic Chemistry Department 01/10/2004 01/03/2005
Faculty of Pharmacy, Cairo University Professor in Pharmaceutical Organic Chemistry Department 01/10/2003 06/05/2014
Faculty of Pharmacy, Cairo University Assistant Professor in Organic Chemistry Department 01/01/1993 01/01/2003
Faculty of Pharmacy, Cairo University Lecturer in Organic Chemistry Department 01/01/1987 01/01/1993
Faculty of Pharmacy, Cairo University Doctoral Candidate in Organic Chemistry Department 01/01/1982 01/01/1987
جامعة القاهرة كلية الصيدلة 06/11/1976 14/09/2013
Faculty of Pharmacy, Cairo University Researcher in Oraganic Chemistry Department 01/01/1976 01/01/1982

Researches /Publications

Some 1, 3, 5-Trisubstituted Pyrazoline Derivatives Targeting Breast Cancer: Design, Synthesis, Cytotoxic activity, EGFR inhibition and Molecular docking - 01/0

Manal Moustafa Hassan Kandeel

• George RF, El-Ansary DY, ElKerdawy AM


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Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7 - 01/0

Manal Moustafa Hassan Kandeel

Mohammed K. Abdelhameid, Eman F. Abdelhaleem, Asmaa E. Kassab


A series of novel tetrahydrobenzothieno[2,3-d]pyrimidine urea derivatives was synthesized according to fragment-based design strategy. They were evaluated for their anticancer activity against MCF-7 cell line. Three compounds 9c, 9d and 11b showed 1.5–1.03 folds more potent anticancer activity than doxorubicin. In this study, a promising multi-sited enzyme small molecule inhibitor 9c, which showed the most potent anti-proliferative activity, was identified. The anti-proliferative activity of this compound appears to correlate well with its ability to inhibit topoisomerase II (IC50 = 9.29 μM). Moreover, compound 9c showed excellent VEGFR-2 inhibitory activity, at the sub-micromolar level with IC50 value 0.2 μM, which is 2.1 folds more potent than sorafenib. Moreover, activation of damage response pathway of the DNA leads to cell cycle arrest at G2/M phase, accumulation of cells in pre-G1 phase and annexin-V and propidium iodide staining, indicating that cell death proceeds through an apoptotic mechanism. Compound 9c showed potent pro-apoptotic effect through induction of the intrinsic mitochondrial pathway of apoptosis. This mechanistic pathway was confirmed by a significant increase in the expression of the tumor suppressor gene p53, elevation in Bax/BCL-2 ratio and a significant increase in the level of active caspase-3. Quantitative structure-activity relationship (QSAR) studies delivered equations of five 3D descriptors with R2 = 0.814. This QSAR model provides an effective technique for understanding the observed antitumor properties and thus could be adopted for developing effective lead structures.

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Synthesis and cytotoxic activity of acridine derivatives substituted with benzimidazole, benzoxazole and benzothiazole - 01/0

Manal Moustafa Hassan Kandeel

Sameeha M. Ali , Mohamed A. Abdelgawad, Mohamed Sadek


Two novel series of 2-(Benzo[d]imidazole/oxazole/thiazole-2-yl))acridine-9(10H)-oneIVa-cand10-(2-((4- (Benzo[d]imidazole/oxazole/thiazole-2-yl)phenyl)amino)-2-oxoethyl)-9-oxo-9,10-dihydroacridine-4-carboxylic acidVIIa-cwere synthesized.The antitumor activity of the prepared compounds was evaluated against human breast cancer (MCF-7), hepatocellular carcinoma (HepG-2) and colon cancer (HCT-116) cell lines using Sulphorhodamine-B (SRB) assay method.Doxorubicin was used as a reference standard. Most of the tested compounds showed potent antitumor activity against HCT-116 cell line with IC50 range equal 4-31μM/mland the compoundVIIcwas the best active one (IC50 = 4.75 μM/ml). VIIashowed the same activity compared to the effect of the reference drug doxorubicin on Hep-2 cell line(IC50 = 3.75 μM/ml). Allof the tested compoundsshowed weak activity against MCF-7 cell line(IC50 = 5.01 μM/ml).

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Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno [2,3-d] pyrimidine and thieno [3,2-e] triazole [4,3-c] pyrimidine derivatives - 01/1

Manal Moustafa Hassan Kandeel

Manal M. Kandeel, Hanan M. Refaat, Asmaa E. Kassab, Inas G. Shahin, Tamer M. Abdelghany


Motivated by the widely reported anticancer activity of thieno[2,3-d]pyrimidines a series of 24 new 2- substitutedhexahydrocycloocta[4,5] thieno[2,3-d]pyrimidines with different substituents at C-4 position and hexahydrocycloocta[4,5]thieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidines were synthesized. The anticancer activity of 17 compounds were evaluated by National Cancer Institute (USA) using a two stage process utilizing 59 different human tumor cell lines representing leukemia, melanoma, cancers of lung, colon, central nervous system (CNS), ovary, kidney, prostate as well as breast. Compound 9c showed broad spectrum potent anticancer activity in nano molar to micro molar range against 56 human tumor cell lines with GI50 less than 10 mM ranging from 0.495 to 5.57 mM, also it is worth mentioning that compound 9c had the marked highest selectivity against the two cell lines T-47D and MDA-MB-468 belonging to breast cancer with GI50 ¼ 0.495 and 0.568 mM respectively, and its effect was further studied on cell cycle progression and induction of apoptosis in the MDA-MB-468 cell line. Results showed that compound 9c induced cell cycle arrest at G2/M phase and also, showed accumulation of cells in pre-G1 phase which may result from, degradation or fragmentation of the genetic materials indicating a possible role of apoptosis in compound 9c-induced cancer cell death and cytotoxicity and verifying this compound as promising selective anticancer lead. Compound 6c was selective against K- 562, SR and MOLT-4 cell lines belonging to leukemia showing growth inhibition percentages 86.38, 65.76 and 60.40 at a single dose test, at the same time it showed lethal activity against HOP-92 representing non-small cell lung cancer. Interestingly, leukemia SR, CNS cancer SNB-75 and renal cancer UO-31 cell lines proved to be sensitive to compound 6d with growth inhibition percentages 52.86, 50.94 and 53.99 respectively. Additionally, compound 6d demonstrated lethal activity to HOP-92 belonging non-small cell lung cancer.

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Award Donor Date
International Publication of Future University in Egypt Future University in Egypt 2015
International Publication of Cairo University Cairo University 2014
International Publication of Cairo University Cairo University 2013
International Publication of Cairo University Cairo University 2012

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