Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Mohamed Ahmed Emad El Gendy

Basic information

Name : Mohamed Ahmed Emad El Gendy
Title: Assistant Lecturer
Personal Info: Mohamed Ahmed Emad, Assistant Lecturer at Pharmaceutics and Pharmaceutical Technology Department. He got his bachelor degree from Cairo University.

Education

Certificate Major University Year
Masters Industrial Pharmacy Cairo University - Pharmacy 2016
Bachelor Pharmacy Cairo University 2010

Teaching Experience

Name of Organization Position From Date To Date
Company NOVARTIS 01/08/2010 31/08/2012

Researches /Publications

Olmesartan medoxomil-loaded self-nanoemulsifying drug delivery systems: design, in-vitro characterization, and pharmacokinetic assessments in rabbits via LC–MS/MS - 01/0

MOHAMED AHMED EMAD ABDELLATIF ELGENDY

M. Ibrahim Tadros and O. Naem El-Gazayerly

01/04/2018

Olmesartan medoxomil (OLM) is a lipophilic (log P = 4.31) antihypertensive drug suffering from limited oral bioavailability in humans (26%) due to its low aqueous solubility, uncontrolled enzymatic conversion to the active metabolite (Olmesartan; OL) and efflux by drug resistance pumps. Surmounting such limitations via incorporation of OLM into self-nanoemulsifying drug delivery systems (SNEDDS). Based on OLM-equilibrium solubility studies in various oils, surfactants and co-surfactants, Capmul® MCM, Tween® 20, Cremophor® EL and polyethylene glycol - 400 (PEG) were combined in different ratios to plot ternary phase diagrams. OLM-loaded SENDDS were developed and evaluated forparticle size, polydispersity index (PDI), zeta potential, self-emulsification time, morphology, drug released percentages after 5-min (Q5min%), 1 hour (Q1h%) and dissolution efficiency percentages (DE1h%). The OL pharmacokinetics from SNEDDS (F6) and Benicar® tablets were evaluated (LC-MS/MS) in rabbits. Spherical OLM-loaded SNEDDS were developed. The best-achieved SNEDDS (F6) showed short emulsification time (13 s), fine droplet size (60.00nm), low PDI (0.25), negative zeta potential (-14.4mV), promising dissolution parameters; Q5min% (29.78%), Q1h% (66.69%) and DE1h% (47.96%) and enhanced in vivo absorption characteristics; shorter Tmax, higher Cmax and larger AUC(0−48h; suggesting its potential for the enhancement of the oral absorption of practically insoluble drugs; like OLM.

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