Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Sara El-Hanboushy

Basic information

Name : Sara El-Hanboushy
Title: Assistant Lecturer
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Personal Info: Sara Abd El-Rasheed, assistant Lecturer of analytical chemistry - Pharmaceutical chemistry Department. She received her bachelor degree of pharmaceutical sciences,faculty of pharmacy, Future University in Egypt-with excellent degree-class 2011. View More...

Education

Certificate Major University Year
Masters . Cairo University - Faculty of Pharmacy 2018
Bachelor Faculty of Pharmaceutical Sciences & Pharmaceutical Industries Future University - Faculty of Pharmaceutical Sciences & Pharmaceutical Industries 2011

Teaching Experience

Name of Organization Position From Date To Date
El Wafaa We El Amal pharmacy community pharmacist 01/10/2011 30/03/2012

Researches /Publications

Spectral analysis of overlapped absorption bands of binary mixture-an application on combination of Pseudoephedrine Sulfate and Loratadine mixture - 01/0

Sara Abdel Rsheed Mohamed Mohamed Elhanboushy

Yasmin M. Fayez

01/09/2019

Background Simple, specific, accurate, and precise spectrophotometric methods are progressed and validated for concurrent analysis of pseudoephedrine sulphate (PSE) and loratadine (LOR) in their combined dosage form depending on spectral analysis procedures. In this binary mixture, pseudoephedrine (PSE) could be determined by using its resolved spectrum of zero-order absorption at 256.8 nm after subtraction of the spectrum of LOR, and also it could be determined in existence of the spectrum of LOR by different methods including absorption correction method (AC) at 256.8 nm and 280 nm, dual wavelength method (DW) at 254 nm and 273 nm, induced dual-wavelength method (IDW) at 230 nm and 263 nm, and ratio difference method (RD) at 256.8 nm and 270 nm. Loratadine (LOR) in the binary mixture could be determined either by direct analysis at 280 nm without any contribution from the spectrum of PSE or through its recovered spectrum of zero-order absorption via constant multiplication method (CM) using plateau region (277–326 nm). Also, concurrent determination for PSE and LOR in their overlapped binary mixture could be achieved by applying induced amplitude modulation (IAM) method. Results Specificity of the proposed spectrophotometric methods was examined by the analysis of prepared mixtures in laboratory and was applied successfully for pharmaceutical dosage form analysis which has the cited drugs without additive contribution. The proposed spectrophotometric methods were also validated as per the guidelines of ICH. Statistical comparison was performed between the obtained results with those from the official methods of the cited drugs, using one-way ANOVA, F test, and Student’s t test, and the results exhibit insignificant difference concerning precision and accuracy. Conclusions The previously proposed spectrophotometric methods could be easily used accurately and precisely for simultaneous determination of the studied binary mixture with simple manipulation procedures.

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Real time selective monitoring of the dissolution behavior of Pseudoephedrine Sulfate and Loratadine in their binary and ternary dosage form by utilization of In-line potentiometric sensor - 01/0

Sara Abdel Rsheed Mohamed Mohamed Elhanboushy

Yasmine M. Fayez

01/05/2019

An electro-analytical procedure was progressed for quantitative determination and monitoring the dissolution behavior of both cationic pseudoephedrine sulfate (PSE sulfate) and loratadine (LOR) drugs in their binary mixture with each other and ternary mixture with paracetamol (PAR) by in-line potentiometric analysis system without a need for pre-treatment or derivatization of the sample. This approach is performed by measuring continuously the increase in the generated emf over time by incorporating an in-site selective electrode for PSE sulfate and LOR fabricated utilizing polymeric membrane of poly (vinyl chloride) (PVC), tetraphenyl borate (TPB) and potassium tetrakis (4-chlorohenyl) borate (KTCPB) as a cation exchanger, Bis(2-ethylhexyl) sebacate and nitrophenyl octyl ether (NPOE), were utilized as plasticizers for determination of PSE sulfate and LOR, conjointly. The proposed sensors for both drugs exhibited stable and fast responses over wide PSE sulfate and LOR concentration range (2 × 10−5 to 2 × 10−2 mol/L regarding PSE sulfate while 1 × 10−5 to 1 × 10−2 mol/L regarding LOR). Afterwards, the proposed potentiometric method's validation was performed, and it is supposed to be eco-friendly and green technique in which consumption of solvents and sample pre-treatment were not mandatory for its application.

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