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Noha Khalil

Basic information

Name : Noha Khalil
Title: Lecturer
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Personal Info: Pharmacist Noha Hassan Khalil,Lecturer of Pharmacognosy, Pharmacognoy and Medicinal Plants Department, She got her M.Sc. degree at Ain Shams University

Education

Certificate Major University Year
PhD Pharmacognosy Cairo University - Faculty Of Pharmacy 2018
Masters Pharmacognosy Faculty of Pharmaceutical Sciences - Ain Shams University 2015
Bachelor Pharmacy Ain Shams 2008

Teaching Experience

Name of Organization Position From Date To Date
Glytone Dermocosmetics Medical Representative 01/01/2008 01/01/2009

Researches /Publications

Ammi Visnaga L., a Potential Medicinal Plant: A Review. - 01/0

NOHA HASSAN KHALIL IBRAHIM

Bishr M, Desouky S

01/01/2020

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Chemical profiling, biostatic and biocidal dynamics of Origanum vulgare L. essential oil - 01/0

NOHA HASSAN KHALIL IBRAHIM

Sahar Fikry

01/03/2019

Origanum vulgare L. (Lamiaceae) is a widespread flavoring culinary and medicinal herb. The present study aimed at investigating the antimicrobial activity of Origanum vulgare (OV) essential oil (EO) through illustrating its biostatic, biocidal and the dynamics of the biocidal activity against 11 different microorganisms. GC/MS of OV EO allowed the identification of 32 compounds representing 99.94% of the oil. The two major identified compounds were terpinen-4-ol (38.35%) and trans-sabinene hydrate (10.06%). Different methods were employed to illustrate the biostatic activity of OV EO. Results of the biostatic studies on OV EO using agar and broth dilution methods showed that Staphylococcus aureus (S. aureus) was the most sensitive organism; with a Minimum inhibitor concentration (MIC) 1.18 mg/ml. Agar diffusion method showed that the highest activity was observed against Bordetella bronchiseptica (Br. bronchiseptica), Saccharomyces cerevisiae (S. cerevisiae), Bacillus subtilis (B. subtilus) and Staphylococcus epidermidis (S. epidermidis) with inhibition zones 38 ± 1.5, 29.5 ± 0.8, 26.9 ± 0.9 and 26.9 ± 1.1 mm, respectively. Studying the dynamics of 1% v/v OV essential oil emulsion over a period of 6 h revealed that Escherichia coli (E. coli), B. subtilis, S. epidermidis and S. cerevisiae had the fastest response. Also increasing concentrations of OV oil emulsion increased the rate of cell killing and the duration of growth lag phase increased correspondingly. These data indicated that OV EO produces a concentration and time-dependent antimicrobial activity.

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Bioassay guided fractio-nation and cytotoxic activity of Daucus carota var. boissieri - 01/0

NOHA HASSAN KHALIL IBRAHIM

Mohamed Ashour, Abdel Naser Singab

01/06/2018

The hexane extract and the hydro-distilled essential oil from red carrot fruits (Daucus carota var. boissieri) were evaluated for their cytotoxic activity against human tumor breast cell lines (MCF-7). Cell viability was evaluated by MTT assay. The extract exhibited good cytotoxic activity shown through its low IC50 (9.12 ± 0.58 μg/ml) against the standard 5-Flououracil (8.46 ± 0.63 μg/ml). Phytochemical investigation of the hexane extract using column chromatography yielded three compounds; 8-methoxypsoralen (1), α-asarone (2) and 3,4,5-trimethoxy-benzaldehyde (3), a compound isolated for the first time from D. carota and from family Apiaceae. Structure elucidation of the isolated compounds was carried out on the basis of their spectral data analysis (IR, MS, 1H NMR an 13C NMR) The three isolated compounds were evaluated for their cytotoxic activity using the same conditions. Only compound (1) exhibited good cytotoxic activity (IC50; 9.38 ± 0.78 μg/ml), compound (2) had moderate activity (46.12 ± 1.31 μg/ml), while compound (3) had no cytotoxic activity (100.6 ± 3.11 μg/ml). These compounds need to be more investigated against other cell lines; also they are considered as a good substrate for future SAR study and modifications to produce more potent cytotoxic derivatives

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Chemical composition and antimicrobial activity of the essential oils of selected Apiaceous fruits - 01/0

NOHA HASSAN KHALIL IBRAHIM

Mohamed Ashour, Sahar Fikry, Abdel Naser Singab

01/06/2018

Antimicrobial properties of plants essential oils are continuously investigated to use them as potential drug candidates to overcome the problem of microbial drug resistance. The aim of this research is to study the antimicrobial effects of the essential oils of ten Apiaceous fruits [Pimpinella anisum L. (anise), Carum carvi L. (caraway), Apium graveolens L. (celery), Coriandrum sativum L. (coriander), Cuminum cyminum L. (cumin), Anethum graveolens L. (dill), Foeniculum vulgare L. (fennel), Petroselinum crispum L. (pasley), Daucus carota L. var. sativus (yellow carrot) and Daucus carota L. var. boissieri (red carrot)]. Results of agar-well diffusion method revealed that the maximum inhibition zones were obtained with cumin, coriander and caraway oils against the standard bacterial strains Escherichia coli, Bordetella bronchiseptica followed by Staphylococcus aureus. Results of viable count time-kill method revealed that coriander oil had the highest antimicrobial activity with more than 99.99% killing of the exposed cells of the standard E. coli and Bordetella bronchiseptica standard strains. GC/MS was carried out to identify the chemical composition of the most active oils. The percentage of identified compounds by GC/MS was 92.5%, 99.43% and 98.66% for cumin, coriander and caraway oils, respectively. Monoterpenes were the most abundant components in the three oils.

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Foliar spraying of salicylic acid induced accumulation of phenolics, increased radical scavenging activity and modified the composition of the essential oil of water stressed Thymus vulgaris L - 01/0

NOHA HASSAN KHALIL IBRAHIM

Mostafa Fekry, Mokhtar Bishr, Soheir El-Zalabani

01/02/2018

Polyphenolic compounds are considered valuable secondary plant metabolites owing to the myriad of biological activities they exert. This study aimed to investigate the effect of applying various concentrations of the plant growth regulator, salicylic acid (SA), on Thymus vulgaris L. while subjecting the plant to decreasing amounts of irrigation water. The following parameters were monitored; total polyphenolic and flavonoid content, yield and composition of the essential oil, and antioxidant activity of the alcoholic extracts. Drought alone significantly (P < 0.05) increased the polyphenolic and flavonoid content, yield of the essential oil and antioxidant activity. The total flavonoid content in control plants was 6.1 ± 0.3 mg/gm dry weight calculated in terms of rutin equivalent. However, in drought stressed plants, (irrigated at 25% of the field capacity) sprayed with 3 mM SA, the flavonoid content increased to 32.1 ± 0.1 mg/gm dry weight calculated in terms of rutin equivalent. Moreover, the total phenolic content increased from 8.5 ± 0.3 to 68.5 ± 1.2 mg/gm dry weight calculated in terms of gallic acid in the same test plants. Radical scavenging activity, using DPPH assay, was measured for the different plant treatments. A decrease from 74.4 ± 0.4 μg/ml to 36.6 ± 0.9 μg/ml of IC50 was recorded in the drought stressed plants (25% FC) sprayed with 3 mM SA compared with the control plants. The variability in polyphenolic composition between the control plants and plants with the highest total polyphenolic content was investigated by UPLC-ESI-MS/MS. Rosmarinic acid was detected as the major component in samples from both treatments, with a higher percentage observed upon subjecting the plant to the test conditions (25% FC and sprayed with 3 mM SA). The highest yield of the essential oil (1 ± 0.06 %v/w) was obtained from drought stressed plants (25% FC) sprayed with 2 mM SA. GC/MS analysis of oil samples revealed that the Thymol content increased with drought stress, while that of p-cymene decreased. However, an increase of p-cymene was witnessed as a result of SA spraying.

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Chemical composition and antimicrobial activity of essential oils of selected Apiaceous plants growing in Egypt - 01/0

NOHA HASSAN KHALIL IBRAHIM

S Fikry, A NaserSingab

01/05/2016

Antimicrobial properties of essential oils of plants are continuously being investigated in order to use them as potential drug candidates to overcome the problem of microbial drug resistance [1]. The aim of this research is to study the antibacterial and antifungal effects of ten traditional Apiaceous essential oils; Pimpinella anisum L. (Anise), Carum carvi L. (Caraway), Apium graveolens L. (Celery), Coriandrum sativum L. (Coriander), Cuminum cyminum L. (Cumin), Anethum graveolens L. (Dill), Foeniculum vulgare (Fennel), Petroselinum crispum L. (Parsely), Daucus carota L. var. sativus (Red Carrot) and D. carota L. var. boissieri (Yellow Carrot).GC/MS was carried out to identify the chemical composition of the most active antimicrobial essential oils. Results of agar-well diffusion method revealed that the maximum inhibition zones were obtained with cumin, coriander and caraway oils against the standard bacterial strains Escherichia coli, Bordetella bronchiseptica followed by Staphylococcus aureus. On the other hand, the remaining essential oils showed much smaller inhibition zones or no inhibition at all. The three most active essential oils; cumin, caraway and coriander were selected to confirm their antibacterial activity by using viable count time-kill method. Results of this experiment revealed that the coriander essential oil had the highest antimicrobial activity with more than 99.999% killing of the exposed cells of the standard E. coli and Bordetella bronchiseptica standard strains during 5 minutes exposure. These results are in accordance with previously published data [2]. The percentage of identified compounds by GC/MS was 92.5, 99.43 and 98.66 for the cumin, coriander and caraway oils respectively. Monoterpenes were the most abundant components in the three oils.

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Chemical Composition and biological activity of the essential oils obtained from yellow and red carrot fruits cultivated in Egypt - 01/0

NOHA HASSAN KHALIL IBRAHIM

Ashour M, Singab AN, Salama O

01/03/2015

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