Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Mai Selim

Basic information

Name : Mai Selim
Title: Lecturer of biochemistry
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Personal Info: Dr/Mai Mostafa Selim , Biochemistry section-Pharmacology,Toxicology and Biochemistry department. She got her Master degree from Ain Shams university and her Doctoral degree from Cairo univeristy. View More...

Education

Certificate Major University Year
PhD Biochemistry Cairo University - Faculty 2015
Masters Biochemistry Ain Shams University - Faculty of Pharmacy 2013
Bachelor . Ain Shams University - Faculty of Pharmacy 2006

Teaching Experience

Name of Organization Position From Date To Date
Future University in Egypt Lecturer of Biochemistry 01/01/2016 01/01/2016
EL azby Pharmacy Currently training 01/01/2007 01/01/2008

Researches /Publications

MicroRNAs 342 and 450 together with NOX‐4 activity and their association with coronary artery disease in diabetes - 01/0

Mai Mostafa Ahmed Mostafa Seleem

01/01/2019

Background Dysregulation of miRNAs has been associated with many clinical conditions, including coronary artery disease (CAD). MiRNAs roles in patients with type 2 diabetes mellitus (T2D) with or without CAD, however, have not been clearly understood. Therefore we studied the expression of miRNAs 342 and 450 and the activity of the NADPH oxidase 4 (NOX‐4), and their association with anthropometric and biochemical parameters of hyperglycaemia and dyslipidaemia. Subjects and Methods Blood was collected from 200 outpatient subjects, divided into four groups of 50 individuals including control, T2D, CAD, and T2D with CAD. CAD was further divided based on CAD with angina, CAD clots, and CAD ischaemia to differentiate the primary cause of CAD. We measured the miRNAs 342 and 450 expression and NOX‐4 activity, in addition to routine parameters. Results The expression of miRNAs 342 and 450 and NOX‐4 activity was significantly different between groups. Furthermore, they presented significant correlations with routine parameters, providing evidence of a potentially beneficial role in stratifying the risk for CAD in patients with T2D. Conclusion The results of this study suggest that the expression of miRNAs 342 and 450 and NOX‐4 activity may help identify those individuals with T2D at high risk for developing CAD as well as the prognosis in those with established CAD.

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MicroRNAs 182 and 375 Sera Expression as Prognostic Biochemical Markers in Breast Cancer - 01/1

Mai Mostafa Ahmed Mostafa Seleem

Ola S. Ali, Heba G. Abdelaziz, Dalia O. Makhlouf

01/12/2018

Breast cancer (BC) is the most common malignancy among women; supporting the need for identification of novel prognostic biomarkers, circulating microRNAs (miRNAs) could serve as such in various cancers. The aim of this study was to explore the association between miRNAs 182 and 375 with BC stages and its receptors, based on their expression using real time PCR. Materials and Methods Detailed medical history was taken and blood samples were withdrawn from 80 female subjects divided over the studied groups. Patients ranged in age from 24 to 80 years and were classified as follows: group I included 10 noncancerous postmenopausal control subjects; group II included 32 postmenopausal patients with BC; group III included 10 noncancerous premenopausal control subjects; group IV included 24 premenopausal patients with BC; and group V included 6 patients with benign breast tumors. Results miRNA 182 expression was significantly higher in group II, group IV, and group V (3.36 ± 0.14, 2.52 ± 0.34, and 4.93 ± 0.3,9 respectively); miRNA 375 expression was significantly higher in group II, group IV, and group V (4.41 ± 0.40, 3.12 ± 0.35, and 11.28 ± 2.37, respectively) (P < .05). Both miRNAs were significantly associated with each other and with receptors used for the prognosis of BC even after multiple regression analysis. Conclusion Accordingly, miRNAs 182 and 375 could be potential noninvasive markers used for the follow up of BC patients.

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Awards

Award Donor Date
best Ta Future university 2013

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