Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Iten Mamdouh Fawzy

Basic information

Name : Iten Mamdouh Fawzy
Title: Lecturer
Personal Info: Iten Mamdouh, lecturer of organic chemistry - Department of pharmaceutical chemistry. She has her bachelor and master degree from Ain-Shams university.

Education

Certificate Major University Year
PhD Pharmaceutical Chemistry Ain Shams University - Faculty of Pharmacy 2018
Masters Pharmaceutical Chemistry Ain Shams University - Faculty of Pharmacy 2013
Bachelor . Ain Shams University - Faculty of Pharmacy 2009

Teaching Experience

Name of Organization Position From Date To Date
Pharmaceutical Chemistry department, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University Assistant Lecturer 01/01/2013 01/01/2016
Pharmaceutical Chemistry department, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University Teaching Assistant 01/01/2009 01/01/2013
Pharmacy Dr. Lobna Pharmacy 01/08/2008 31/10/2008

Researches /Publications

N-substituted-piperidines as novel anti-alzheimer agents: Synthesis, antioxidant activity, and molecular docking study - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/06/2018

Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described. Then, a series of hybrids have been developed by introducing Free radical scavengers. Molecular modeling was performed and structure activity relationships are discussed. Among the series, most potent compounds showed effective AchE inhibitions, high selectivity over butyrylcholinesterase and high radical scavenging activities. On the basis of this work, the ability of analogs containing nipecotic acid scaffold to serve in the design of N-benzyl-piperidine linked multipotent molecules for the treatment of Alzheimer Disease.

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Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

Deena S Lasheen, Khaled AM Abouzid

01/05/2018

Aim: Imatinib possesses various mechanisms for combating cancer, making the development of imatinib analogs an attractive target for cancer research. Method: Two series of analogs were designed and synthesized, maintaining the essential pharmacophoric features in imatinib structure. The synthesized compounds were subjected to cell-based antiproliferative assays against nonsmall lung (A549) and colon cancer cell lines. In addition, flow cytometry cell cycle and caspase-3 colorimetric assays were performed. Results: Most compounds showed potent anticancer activity against both cell lines with IC50 = 0.14–5.07 μM. Three compounds demonstrated ability to reinforce cell cycle arrest at G1 stage in a manner similar to imatinib. In addition, they induced apoptosis via activation of caspase-3.

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N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

Prof. Dr. Khairia Youssef, Prof. Dr. Hussein I. El-Subbagh

01/07/2017

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“Design and synthesis and biological evaluation of novel curcumin analogs with anticipated anticancer activity”Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

Khairia M. Youssef, Nasser S.M. Ismail, J. Gullbo, Khaled A.M. Abouzid

01/06/2015

Extensive research conducted within past years revealed that curcumin is a highly pleiotropic molecule that interacts with a diverse range of molecular targets and hence it possess anti-proliferative activities against tumor cells.The great similarities between curcumin analogs and chalcones inspired their testing against tubulin enzyme activity as recent research revealed that chalcones possess cytotoxic activity associated with tubulin inhibition and interference with microtubule formation, which is essential in mitosis and cell replication.

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Newly designed and synthesized curcumin analogs with in vitro cytotoxicity and tubulin polymerization activity - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2014

Journal of Chemical Biology and Drug Design

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Molecular docking and in silico ADME study of Novel N9-substituted Purines targeting CK1 and abl-tyrosine kinase - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2014

FIP Bangkok

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“Modeling and synthesis of novel curcumin analogs with anticipated anticancer activity”Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J.Gulbo, Khaled A.M. Abouzid - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2013

Molecular Modeling and biology assays for curcumin analogs

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“Modeling and synthesis of novel curcumin analogs with anticipated anticancer activity” - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2013

sybthesis and molecular modeling study of new anticancer drugs together with their biological evaluation

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“Design and synthesis and biological evaluation of novel curcumin analogs with anticipated anticancer activity” - 01/0

Iten Mamdouh Fawzy Abdelmotaleb

01/01/2013

Synthesis of new anticancer drugs and their biological evaluation

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Awards

Award Donor Date
Best Research Presentation FUE 3rd International conference of Pharmaceutical Sciences, Intercontinental-Citystars, Cairo, Egypt 2015
Azzazy Award for outstanding Teaching Assistant Opera Hall, Fue Ceremony, Cairo, Egypt 2015
FUE Outstanding Teaching Assistant Opera Hall, FUE Ceremony, Cairo, Egypt 2014

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