Future University In Egypt (FUE)
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Miriam Fouad Yousif

Basic information

Name : Miriam Fouad Yousif
Title: Professor
Google Schoolar Link
Personal Info: Dr. Miriam F. Yousif, Professor of Pharmacognosy, Head of Pharmacognosy and Medicinal Plants Department. She got her Ph.D. at Cairo University


Certificate Major University Year
PhD Pharmacognosy Cairo University - Faculty of Pharmacy 1996
Masters Pharmacongosy Cairo University - Faculty of Pharmacy 1989
Bachelor . Cairo University - Faculty of Pharmacy 1984

Teaching Experience

Name of Organization Position From Date To Date
Cairo University Professor 01/12/2011 14/03/2012

Researches /Publications

Entada rheedii seeds thioamides, phenolics, and saponins and its antiulcerogenic and antimicrobial activities - 01/0

Miriam Fouad Yousif Hanna

Mona M. Okba, Sally A.W. El Awdan, Kadriya S. El Deeb, Fathy M. Soliman


Entada rheedii (Fabaceae) seeds are used against diarrhea and stomach aches. This study aims at scientifically validate its ethnomedicinal uses. Seeds ethanol (70%) extract (EE) was prepared by percolation. Antibacterial and antiviral activities of EE and isolated compounds were determined using agar well diffusion and MTT assays, respectively. Anti-ulcerogenic activity was evaluated using ethanol-induced ulcer model. Four phenolics: protocatechuic acid C1, protocatechuic acid methyl ester C2, 1,3,4-trihydroxybenzene glucoside C3, phaseoloidin C4, three thioamides: entadamide A C5, entadamide A-β-d-glucopyranoside C6, entadamide C C7, and two saponins: rheedeioside A C8 and rheedeioside B C9 were isolated from EE. EE, C4, C5, and C8 evidenced significant (p ˂ 0.05) antiulcerogenic activity. Strong antibacterial activity was reported for EE, C1, and C7. C4 exhibited moderate (35% inhibition) antiviral activity. This study provides scientific validation of the seed ethnomedicinal use in treating gastric ailments and as antimicrobial.

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Vicia ervilia L. seeds newly explored biological activities - 01/0

Miriam Fouad Yousif Hanna

2. Mona M. Okba, Gehad A. Abdel Jaleel, Kadrya SH. El Deeb & Fathy M. Soliman


Within the global context of increasing poverty in the developing countries, natural products are important in devising new drugs. Vicia ervilia L. Willd., unlike several fabaceae seeds, is not used for human consumption till now. We aim to discover any possible medicinal use of the seed. Analgesic, anti-inflammatory, antiulcerogenic and antihyperglycemic activities were evaluated using hot plate, carrageenan-induced rat paw edema, ethanol-induced ulcer model and alloxan-induced diabetes methods, respectively. Antiviral activity was evaluated using Methylthiazol Tetrazolium assay. V. ervilia seeds ethanol (70%) extract had significant anti-inflammatory, analgesic, antiulcerogenic, antihyperglycemic and antiviral activities. It is of excellent choice for treatment of several illnesses in developing countries due to its diverse resource, easy accessibility, affordability and its newly proved significant wide range of biological activities.

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Microscopical, physicochemical and nutritional characterization of three herbal hepatoprotectives - 01/0

Miriam Fouad Yousif Hanna

Issa M. Y., El Zalabani S. M., El-Askary H. I., Salah El-Dine R.


Plant-based health products play, nowadays, an important role in the global drug market. Despite this constant rise in commercial importance, the processing of herbal drugs lacks reliable scientific assessment and is often performed without strict regulations. To guarantee the quality of the final product, well-defined specification criteria should be established for raw materials before manufacture. The quality and correct identity of crude powdered plants or plant organs can be checked via inspection of sensory, microscopical and physicochemical characteristics. Liver disorders represent a threatening health problem in Egypt. Herbs are frequently used as supportive complementary remedies to alleviate these ailments. The objective of this study was to establish reliable criteria for proper identification of three hepatoprotective herbal drugs viz., seeds of Linum usitatissimum L. (flaxseeds) and Trigonella foenumgraecum L. (fenugreek seeds), and leaves of Rosmarinus officinalis L. (rosemary leaves). The powdered samples were microscopically examined and subjected to proximate, physicochemical and nutritional analysis. The present work will, thus, provide helpful information on the quality of these herbal materials to ensure genuineness, safety and efficacy prior incorporation in pharmaceutical formulations. Key words: Quality control, flax, fenugreek, rosemary, hepatoprotective.

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Botanical study, DNA fingerprinting, nutritional values and certrain proximates of Vicia ervilla L. - 01/0

Miriam Fouad Yousif Hanna

Okba M, El Deeb K, Soliman F.


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Miriam Fouad Yousif Hanna


Entada rheediiSpreng. (Family Fabaceae) seeds are used in Egypt in folk medicine.Macro- and micro-morphological characters of E. rheedii Spreng.seeds imported from India together with that of roots, stems and leaves cultivated in Egypt were presented with the aim of their identification in entire and powdered forms. Cultivation in Egypt gave a climbing plant instead of the huge fruiting trees bordering the Indian Ocean. Plant materials were fixed, freehand sectioned and stained with Safranin. Leaves are compound, bipinnate; their blades exhibit rubiaceous and few ranunculaceous stomata, non-glandular trichomes and dorsiventral mesophyll. The stem upper part is cylindrical with six ridges. The stem has relatively wide pith surrounded by open collateral vascular bundles. Study of Deoxyribonucleic acid (DNA) fingerprinting, total seed protein profiling, nutritional value and certain proximates was carried out in order to contribute to the identification of the plant material.A total of 53 different fragments have been recorded in DNA fingerprinting, produced mainly by (A-19) primer, showing 15 bands ranging from 1.337 Kbp to 0.356 Kbp,Eight bands were recorded in seed total protein banding profile of E. rheedii Spreng seed with molecular weights ranging from 52 to 9 KDa.High levels of Glutamic acid and Phenyl alanine amino acids were determined.Moisture, carbohydrates and ash percentages were 7.35, 16.47 and 2.83 respectively. Evaluation of macroelements (Ca, Na, K and P); and microelement (Fe) revealed that potassium (K) and phosphorous (P) occupied the highest positions (1264 and 1240 mg/100 g seeds respectively) among the macroelements, whereas the micro element Iron (Fe) level was 3.3 mg/100 g seeds.

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