Future University In Egypt (FUE)
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Altagamoa Al Khames, Main centre of town, end of 90th Street
New Cairo
Egypt

Hussein Ammar

Basic information

Name : Hussein Ammar
Title: Professor of Pharmaceutical Technology and Clinical Pharmacy
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Personal Info: Prof. Dr. Hussein Ammar, head of pharmaceutics and Pharmaceutical Technology Department and former Dean, Pharmacy Division of the National Research Centre. Prof. Ammar is a holder of the First Class Medal of Sciences and Arts. He is the recipient of the 2010 Appreciation State Prize in Advanced Technological Sciences. View More...

Education

Certificate Major University Year
PhD (Pharmaceutical Sciences (Pharmaceutics Cairo University - Faculty of Pharmacy 1970
Masters Pharmaceutics Cairo University - Faculty of Pharmacy 1968
Bachelor pharmacy Cairo University 1964

Teaching Experience

Name of Organization Position From Date To Date
Faculty of Pharmacy, Future University in Egypt Teaching undergraduate students, Pharmaceutical Technology and Clinical Pharmacy 01/01/2008 04/05/2014
6th October University Teaching undergraduate students, Pharmaceutics and Physical Pharmacy 01/01/2007 01/01/2008
Faculty of Pharmacy, Canal University, Suez Teaching undergraduate students, Pharmaceutical Technology and Physical Pharmacy 01/01/2001 04/05/2014
Faculty of Pharmacy, Canal University, Suez Teaching postgraduate students, Physical Pharmacy 01/01/2001 04/05/2014
Faculty of Pharmacy, Assuit University Teaching postgraduate students, Physical Pharmacy 01/01/1976 01/01/1980
Faculty of Pharmacy, Assuit University Teaching undergraduate students, Pharmaceutical Technology and Physical Pharmacy 01/01/1976 01/01/1980
National Research Center Professor 01/01/1965 31/01/2012

Researches /Publications

Development of folic acid–loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab MM, Mostafa DM, Abd El-Alim SH, Kassem AA, Salah S, Shalaby ES

01/05/2020

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Development of folic acid–loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ammar HO, Ghorab MM, Mostafa DM, Abd El-Alim SH, Kassem AA, Salah S, Shalaby ES.

01/04/2020

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Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Shamma RN, Elbatanony RS, Khater B

01/03/2020

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Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ammar HO, Shamma RN, Elbatanony RS, Khater B.

01/01/2020

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Therapeutic strategies for erectile dysfunction with emphasis on recent approaches in nanomedicine. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Tadros MI, Salama NM

01/09/2019

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Therapeutic strategies for erectile dysfunction with emphasis on recent approaches in nanomedicine. I - 01/0

HUSSEIN OSMAN HASSAN AMAR

Tadros MI, Salama NM, Ghoneim AM

01/09/2019

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Therapeutic strategies for erectile dysfunction with emphasis on recent approaches in nanomedicine - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mina Tadros, Nahla M. Salama

01/09/2019

This review addressed erectile dysfunction, regarding pathophysiology and therapeutic strategies. The line of treatment includes phosphodiesterase type-5 inhibitors and other types of therapy like topical and stem-cell transplant. Scientific literature was assessed to investigate the impact of nanotechnology on erectile dysfunction therapy. Various nanotechnology approaches were applied, like vesicular systems, lipid-based carriers, nanocrystals, dendrimers, liquid crystalline systems and nanoemulsions. Smart nano-systems can alter the landscape of the modern pharmaceutical industry by re-investigation of pharmaceutically suboptimal but biologically active entities for treatment of erectile dysfunction which were previously considered undeveloped.

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Schizophernia: Stages approaches in treatment and future prospects - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mahmoud M. Ghorab

01/08/2019

This review gives a summary of the stages of schizophrenia, first and second-generation antipsychotics development and the techniques used in their formulations. These methods aim to improve the dissolution of these drugs and hence bioavailability, or to be formulated in controlled release forms, or to improve the brain targeting efficiency

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Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension - 01/0

HUSSEIN OSMAN HASSAN AMAR

Bhavani Prasad Vinjamuri, Rehab N. Shamma, Mahmoud M. Ghorab, Mahavir Bhupal Chougule,Lipika Chablani

01/05/2019

Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried hydrogel microparticles containing biodegradable sodium carboxymethyl cellulose, sodium alginate, and sodium hyaluronate polymers at variable concentrations were prepared. A design of experiment using the “Extreme Vertices Mixture” design was executed. The design was used to study the influence of polymer concentration and their interactions on the physicochemical properties of the formulations in terms of particle size, particle size distribution, product yield, entrapment efficiency, and in-vitro drug release. Selected formulations were also evaluated for swelling, biodegradation, moisture content, in-vitro aerodynamic performance, and cytotoxicity. In addition, a lung deposition and pharmacokinetic study was conducted in rats to study drug accumulation in lungs and blood after intratracheal administration of the spray dried inhalable hydrogel microparticles in comparison to orally administered Viagra®. The results demonstrated that formulated microparticles had a mean geometric particle size between 2 and 5 μm, entrapment efficiency of >80%, and yield ranging between 47 and 66% w/w. The in-vitro drug release profiles showed a sustained drug release of sildenafil citrate for over 24 h. The statistical design showed a significant influence of the microparticulate composition on the physicochemical properties. Furthermore, selected formulations were evaluated for their aerodynamic properties. The aerodynamic properties included fine particle fraction ranging between 24 and 30%, dose recovery percent of 68–8 5%, and average mass median aerodynamic diameter of 4.6–4.8 μm. The in-vivo pharmacokinetic study showed that inhaled spray dried hydrogel microparticles (M6) formulation had significantly higher lung/blood Cmax, AUC, extended half-life, and mean residence time in comparison to orally administered sildenafil citrate of the same dose. In conclusion, the formulated drug-loaded spray dried hydrogel microparticles showed promising in-vitro and in-vivo results for the pulmonary delivery of sildenafil citrate. The spray dried hydrogel microparticles formulation can be considered as a potential alternative of oral sildenafil citrate for treatment of PAH.

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Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl pharmacokinetic study in healthy volunteers - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mahmoud M.Ghorab, Dina M. Mostafa

01/06/2018

Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for in vitro release profi le in comparison to the marketed product [Lustral® tablets]. The in vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations. Results: In vitro release data showed signifi cant improvement of dissolution rate of sertraline HCl in form of liquid SNEDDS compared to the plain drug. Optimized liquid SNEDDS were chosen for the preparation of solid SNEDDS by spray drying technique. High dissolution effi ciency values of solid SNEDDS indicated the increase in dissolution characteristics of sertraline HCL in solid SNEDDS. F6 SNEDDS, comprising Capmul® 20%, Cremophor® 53.4%, Transcutol® 26.6% showed highervalues for AUC[0-72 h], AUC [0-∞] and AUMC[0-72h] compared to Lustral® tablets. Conclusion: The prepared formulation reveals the potentiality of incorporating sertraline HCl in a SNEDDS formulation to improve the biological performance of the drug.

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Transdermal Delivery of Ondansetron Hydrochloride via Bilosomal Systems: In Vitro, Ex Vivo, and In Vivo Characterization Studies - 01/0

HUSSEIN OSMAN HASSAN AMAR

Magdy Ibrahim Mohamed, Mina Ibrahim Tadros

01/05/2018

Ondansetron hydrochloride (OND) is commonly used for management of postoperative and chemotherapeutic-induced nausea and vomiting. It suffers from low bioavailability (60%) and rapid elimination (t1/2; 3–4 h). The current work aimed to develop OND-loaded bilosomes as a promising transdermal delivery system capable of surmount drug limitations. The variables influencing the development of OND-loaded bilosomes and niosomes (18 systems) via the thin film hydration technique were investigated, including surfactant type (Span®60 or Span®80), surfactant/cholesterol molar ratio (7:0, 7:1, or 7:3), and sodium deoxycholate (SDC) concentration (0, 2.5, or 5%, w/v). The systems were characterized for particle size, polydispersity index, zeta potential, drug entrapment efficiency (EE%), and in vitro permeation. Based on factorial analysis (32·21) and calculations of desirability values, six systems were further subjected to ex vivo permeation through excised rat skin, differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD), and transmission electron microscopy. Histopathological and in vivo permeation studies in rats were conducted on the best achieved system (B6) in comparison to drug solution. Higher desirability values were achieved with Span® 60-based bilosomes, surfactant/cholesterol molar ratio of 7:1, and SDC concentration of 2.5% w/v with respect to small vesicle size, polydispersity index and high zeta potential, EE%, and cumulative drug permeation. OND was dispersed in amorphous state as revealed from DSC and PXRD studies. No marked effect was observed in rat skin following application of B6 system while higher ex vivo and in vivo cumulative permeation profiles were revealed. Bilosomal systems were considered as safe and efficient carriers for the transdermal delivery for OND

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Lamotrigine loaded poly-ɛ-(d, l-lactide-co-caprolactone) nanoparticles as brain delivery system - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mahmoud M. Ghorab, Iman M. Higazy

01/03/2018

Management of epilepsy requires brain delivery therapy, therefore, this study was aimed to prepare lamotrigine loaded poly-ɛ-(d,l-lactide-co-caprolactone) (PLCL) nanoparticles using spontaneous emulsification solvent diffusion method. Nanoparticles for brain delivery required to have a particle size <200 nm, polydispesity index <0.2 and a sustained drug release properties. For such aim different factors were considered in preparing the nanoparticles as PLCL monomers' ratio, type of organic solvent used to prepare the nanoparticles, amount of PLCL and Pluronic®F127 in the nanoparticles. Prepared nanoparticles were characterized for their shape, particle size, polydispersity index, zeta potential, encapsulation efficiency, drug loading capacity, process yield and in-vitro drug release pattern. The in-vivo investigation for brain delivery of selected nanoparticles delivered by intravenous route was investigated in rats and compared to that for oral tablet. The obtained nanoparticles were spherical in shape. The amount of surfactant and PLCL affected the properties of the obtained nanoparticles. Using a mixture of organic solvent in preparing the nanoparticles improved its properties. The nanoparticles prepared using PLCL with monomers' ratio of 25:75, had particle size value of 125 nm, polydispersity index value of 0.184, zeta potential value of −39 mV and encapsulation efficiency value of 99%, was selected to study their efficacy to deliver the drug to the brain. The tested nanoparticles showed higher values of Tmax, Cmax, AUC, and MRT in homogenized rat brain, compared to oral lamotrigine tablet, while the bioavailability of the oral tablet was higher in rat plasma compared to that for the nanoparticles. This reflects that brain was the main distribution site for tested nanoparticles, and plasma was the main distribution site for oral tablets. This confirms the goal of the selected formulation as brain delivery nanoparticles.

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In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration. - 01/0

HUSSEIN OSMAN HASSAN AMAR

M. Haider , M. Ibrahim

01/02/2017

Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release. A parallel design was adopted to evaluate the pharmacokinetic performance of DTZ-loaded niosomes in male Wistar rats. Non-compartmental analysis was performed where Cmax, Tmax, t1/2, MRT, area under the release curve (AUC) and Ke were assessed. The prepared niosomes were spherical with mean particle size 0.82–1.59 μm. Span 60-cholesterol niosomes (1:1 molar ratio) showed the highest entrapment and release efficiencies. In vivo study revealed an increase in MRT, t1/2 and AUC with a decrease in Ke. In conclusion, nasal niosomal formulation of DTZ expressed suitable pharmacokinetic parameters and bioavailability through prolonged duration of action inside the body as well as low rate of elimination depicting a promising alternate to the conventional oral route.

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Antiinflammatory sunscreen nanostructured lipid carrier formulations. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Fatma S.Abdel-Salam

01/02/2017

Discoid lupus erythematosus is a condition of chronic inflammation of the skin which requires protection from ultraviolet radiations and prolonged treatment with topical corticosteroids. The aim of this study was to prepare semisolid nanostructured lipid carrier (NLC) formulations containing diflucortolone valerate (DFV) as a model corticosteroid drug and titanium dioxide (TiO2) as an inorganic UV-filter in the same formulation. The NLC formulations were prepared by applying high shear homogenization and ultrasonication techniques using Precriol®ATO5 or Tristearin® as the solid lipids, Capryol™ or isopropyl myristate as the liquid lipids, Poloxamer® 407 as a surfactant and Labrafil® M1944CS as a lipid based surfactant. The incorporation of TiO2 in the NLCs in concentration of 5% w/w was found to be the optimum concentration which enhances the intrinsic sun protection factor (SPF) of this carrier system and resulted in suitable sun protection values ranged from 4.94 to 21.27 with an acceptable spreadable consistency for the NLC formulation. Semi-solid NLC formulations were characterized by small particle size ranged from 180.8 to 255.1 nm before the addition of TiO2 and the particle size reached 540.1 nm after addition of 5% TiO2. Incorporation of TiO2 in NLC formulations leads to a synergistic photoprotection and increase patient compliance.

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Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Fatma S. Abdel-Salam

01/01/2017

Context: Topical treatment of skin disease needs to be strategic to ensure high drug concentration in the skin with minimum systemic absorption. Objective: The aim of this study was to produce semisolid nanostructured lipid carrier (NLC) formulations, for topical delivery of the corticosteroid drug, diflucortolone valerate (DFV), with minimum systemic absorption. Method: NLC formulations were developed using a high shear homogenization combined with sonication, using Precirol® ATO5 or Tristearin® as the solid lipid, Capryol™ or isopropyl myristate as the liquid lipid and Poloxamer® 407 as surfactant. The present study addresses the influence of different formulations composition as solid lipid, liquid lipid types and concentrations on the physicochemical properties and drug release profile from NLCs. Results and discussion: DFV-loaded NLC formulations possessed average particle size ranging from 160.40 nm to 743.7 nm with narrow polydispersity index. The encapsulation efficiency was improved by adding the lipid-based surfactants (Labrasol® and Labrafil® M1944CS) to reach 68%. The drug release from the investigated NLC formulations showed a prolonged release up to 12 h. The dermatopharmacokinetic study revealed an improvement in drug deposition in the skin with the optimized DFV-loaded NLC formulation, in contrast to a commercial formulation. Conclusion: NLC provides a promising nanocarrier system that work as reservoir for targeting topical delivery of DFV.

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Design and in vitro/in vivo evaluation of ultra-thin mucoadhesive buccal film containing fluticasone propionate. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mahmoud M. Ghorab,

01/01/2017

Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent anti-inflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically acceptable and could maintain local drug release for a sustained period to manage the sign and symptoms of severe erosive mouth lesions. Solvent casting technique was used in film preparation. Different polymeric blends were used either alone or in combination with mucoadhesive polymers, sodium carboxymethyl cellulose (SCMC), or Carbopol 971P at different concentrations. The physicochemical properties, in vitro mucoadhesion time as well as the drug release properties for all prepared formulations were determined. Selected formulations with adequate properties were further examined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) and subjected to in vivo evaluation. Films containing hydroxypropyl methylcellulose (HPMC)/ethyl cellulose (EC) showed acceptable physicochemical properties, homogenous drug distribution, convenient mucoadhesion time, moderate swelling as well as sustained drug release up to 12 h. The biological performance of these formulations was assessed on healthy human volunteers and compared with a prepared mouthwash which showed enhanced pharmacokinetic parameters for the selected films in comparison to the mouthwash. The results revealed that the optimized formulation containing HPMC/EC and 10% SCMC could successfully achieve sustained drug release for 10 h which is considered promising for local treatment of severe mouth lesions.

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Formulation of risperidone in floating microparticles to alleviate its extrapyramidal side effects - 01/1

HUSSEIN OSMAN HASSAN AMAR

Mahmoud M. Ghorab, Shereen H. Noshi

01/12/2016

Risperidone is effective in the treatment of positive as well as negative symptoms of schizophrenia. But, there is a strong correlation between plasma levels of risperidone and its adverse effects. Objective This study aimed to develop risperidone in floating microparticles to overcome its extrapyramidal side effects. Methods Floating microparticles were prepared using Eudragit S100, hydroxypropylmethyl cellulose (HPMC), Gelucires (Gelucire 43/01 pellets, Gelucire 44/14 and Gelucire 50/13), Geleol mono and diglyceride NF, glyceryl monostearate, Compritol 888 ATO, methyl-betacyclodextrin (MβCD) and hydroxypropyl-betacyclodextrin (HPβCD), by emulsion solvent diffusion technique. In-vitro experiments were conducted to optimize formulation parameters regarding floating ability, yield value, drug loading and in-vitro release properties. The best formula was investigated for its in-vivo floating ability and for its pharmacokinetics as well as its extrapyramidal side effects in human volunteers. Results The optimized floating microparticles showed promising in-vitro experiment performance with floating ability up to 95.93% for 12 h. Also, this floating ability was confirmed using in-vivo x-ray studies. Pharmacokinetics studies revealed significant (p < 0.05) lower Cmax, longer Tmax and higher AUC values for the optimized formula compared to the marketed oral product (Risperidal® 4 mg tablets) indicating gradually release properties which lead to high treatment efficacy of the drug with obvious reduced extrapyramidal side effects. Conclusion These results proved that formulating risperidone as floating microparticles is a suitable dosage form for overcoming risperidone side effects.

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Formulation of risperidone in floating microparticles to alleviate its extrapyramidal side effects - 01/1

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M. M, Noshi, S.H.

01/12/2016

Abstract Risperidone is effective in the treatment of positive as well as negative symptoms of schizophrenia. But, there is a strong correlation between plasma levels of risperidone and its adverse effects. Objective This study aimed to develop risperidone in floating microparticles to overcome its extrapyramidal side effects. Methods Floating microparticles were prepared using Eudragit S100, hydroxypropylmethyl cellulose (HPMC), Gelucires (Gelucire 43/01 pellets, Gelucire 44/14 and Gelucire 50/13), Geleol mono and diglyceride NF, glyceryl monostearate, Compritol 888 ATO, methyl-betacyclodextrin (MβCD) and hydroxypropyl-betacyclodextrin (HPβCD), by emulsion solvent diffusion technique. In-vitro experiments were conducted to optimize formulation parameters regarding floating ability, yield value, drug loading and in-vitro release properties. The best formula was investigated for its in-vivo floating ability and for its pharmacokinetics as well as its extrapyramidal side effects in human volunteers. Results The optimized floating microparticles showed promising in-vitro experiment performance with floating ability up to 95.93% for 12 h. Also, this floating ability was confirmed using in-vivo x-ray studies. Pharmacokinetics studies revealed significant (p < 0.05) lower Cmax, longer Tmax and higher AUC values for the optimized formula compared to the marketed oral product (Risperidal® 4 mg tablets) indicating gradually release properties which lead to high treatment efficacy of the drug with obvious reduced extrapyramidal side effects. Conclusion These results proved that formulating risperidone as floating microparticles is a suitable dosage form for overcoming risperidone side effects.

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In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration - 01/1

HUSSEIN OSMAN HASSAN AMAR

Haider, M., Ibrahim, M

01/11/2016

Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release. A parallel design was adopted to evaluate the pharmacokinetic performance of DTZ-loaded niosomes in male Wistar rats. Non-compartmental analysis was performed where Cmax, Tmax, t1/2, MRT, area under the release curve (AUC) and Ke were assessed. The prepared niosomes were spherical with mean particle size 0.82–1.59 μm. Span 60-cholesterol niosomes (1:1 molar ratio) showed the highest entrapment and release efficiencies. In vivo study revealed an increase in MRT, t1/2 and AUC with a decrease in Ke. In conclusion, nasal niosomal formulation of DTZ expressed suitable pharmacokinetic parameters and bioavailability through prolonged duration of action inside the body as well as low rate of elimination depicting a promising alternate to the conventional oral route.

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Preformulation studies intended for targeted lamotrigine polymeric nanosuspension - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M. M, Mahmoud, A. A., Higazy, I. M

01/09/2016

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Anti-inflammatory sunscreen nanostructured lipid carrier formulations - 01/0

HUSSEIN OSMAN HASSAN AMAR

Abdel-Salam, F. S., Mahmoud, A. A., and Elkheshen, S. A

01/06/2016

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Preparation and Characterization of a Novel Injectable Vesicles - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ibrahim, M., Mahmoud, A., Shamma, R. and El Hoffy, N.,

01/06/2016

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Design and in-Vitro/in-Vivo Evaluation of Ultra –Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.M., Mahmoud, A.A. and Shahein, H

01/02/2016

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Nanostructured Lipid Carriers as Semisolid Topical Delivery Formulations for Diflucortolone Valerate - 01/0

HUSSEIN OSMAN HASSAN AMAR

Abdel–Salam, F.S., Mahmoud, A.A., and Elkheshen, S.A.

01/02/2016

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A trial for the design and optimization of pH-sensitive microparticles for intestinal delivery of cinnarizine - 01/0

HUSSEIN OSMAN HASSAN AMAR

Mahmoud Ghorab. Rabab Kamel. Alaa H. Salama

01/01/2016

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Design and Optimization of Gastro-Retentive Microballoons for Enhanced Bioavailablity of Cinnarizine - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.M., Kamel, R. and Salama, A.H

01/01/2016

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Folic Acid Loaded Lipid Nanocarriers with Promoted Skin Antiaging and Antioxidant Efficacy - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.M., Mostafa, D. M. and Ibrahim E.S

01/01/2016

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Diflucortolone Valerate Loaded Solid Lipid Nanoparticles as a Semisolid Topical Delivery System - 01/0

HUSSEIN OSMAN HASSAN AMAR

Abdel-Salam, F.S., Elkheshen, S.A. and Mahmoud, A.A.,

01/01/2016

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Effect of antiadherents on the physical and drug relese properties of acrylic polymeric films. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.; Felton, L.A.; Gad, S. and Fouly, A.A.

01/01/2015

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Development and evaluation of floating gastroretentive microspheres for modified release of risperidone. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.; Mahmoud, A.A; and Noshi, S.H.

01/01/2014

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Enhancement of oral bioavailability of repaglinide by self-nanoemulsifying drug delivery sytem. - 01/0

HUSSEIN OSMAN HASSAN AMAR

El-Feky, G.S.; Abdelhaleem A.; Galil, D. and Rami, A.

01/01/2014

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Self-nanoemulsifying drug delivary system for sertraline hydrochloride: Design, preparation and characterization. - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.; Mostafa, D.M.; and Ghoneim, A.M.

01/01/2014

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Rapid pain relief using transdermal film forming polymeric solution of ketorolac - 01/0

HUSSEIN OSMAN HASSAN AMAR

Ghorab, M.; Mahmoud, A.A; Makram, T.S. and Ghoneim, A.M.

01/01/2013

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Awards

Award Donor Date
وسام العلوم و الفنون من الطبقة الاولى رئاسة الجمهورية 2013
First Class Medal of Sciences and Arts President of Arab Republic of Egypt 2013
The State Appreciation Prize in Advanced Technological Sciences The Academy of Scientific Research and Tecnology 2010
جائزة الدولة التقديرية فى العلوم التكنولوجية المتقدمة التى تخدم العلوم الطبية أكاديمية البحث العلمى والتكنولوجيا 2010
الجائزة التقديرية للمركز القومى للبحوث المركز القومى للبحوث 2009
The National Research Center Prize for Scientific Appreciation National Research Center 2009
جائزة "سكوبس" لافضل نشر في المجلات العلمية العالمية وزارة التعليم العالي و الدولة للبحث العلمي 2008
The Scopus Award for Scientific Contribution to Pharmacology Scopus- Ministry of Higher Education and Scientific Research 2008
جائزة التفوق العلمى للمركز القومى للبحوث المركز القومى للبحوث 1994
The National Research Center Prize for Scientific Distinction National Research Center 1994

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